Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.
A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.
Romaric Bouveret, Ashley J Waardenberg ... Richard P Harvey
Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.
The introduction of rapid diagnostic testing for Plasmodium falciparum infections can explain an increased emergence of diagnostic resistant pfhrp2-deleted parasites in sub-Saharan Africa.
Firas Bou Daher, Yuanjie Chen ... Siobhan A Braybrook
Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
Human mobility drives malaria importation within countries and threatens elimination interventions, but can be measured using new approaches that combine parasite genetics, mobile phone data, travel surveys and models.