66 results found
    1. Cell Biology
    2. Developmental Biology

    Coordinated genomic control of ciliogenesis and cell movement by RFX2

    Mei-I Chung, Taejoon Kwon ... John B Wallingford
    Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly

    Sabina Schütz, Ute Fischer ... Vikram G Panse
    The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

    Brenda Y Han, Shuang Wu ... Jason G Cyster
    A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.
    1. Developmental Biology

    NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

    Romaric Bouveret, Ashley J Waardenberg ... Richard P Harvey
    Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.
    1. Biochemistry and Chemical Biology

    Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation

    Cohue Peña, Sabina Schütz ... Vikram G Panse
    The ATPase Fap7 prefabricates a uS11:eS26 ribosomal protein complex for ribosome assembly.
    1. Epidemiology and Global Health

    Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa

    Oliver J Watson, Hannah C Slater ... Azra C Ghani
    The introduction of rapid diagnostic testing for Plasmodium falciparum infections can explain an increased emergence of diagnostic resistant pfhrp2-deleted parasites in sub-Saharan Africa.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu, Yolanda T Chong ... Alan M Moses
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.
    1. Plant Biology

    Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry

    Firas Bou Daher, Yuanjie Chen ... Siobhan A Braybrook
    Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
    1. Epidemiology and Global Health

    Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

    Hsiao-Han Chang, Amy Wesolowski ... Caroline Buckee
    Human mobility drives malaria importation within countries and threatens elimination interventions, but can be measured using new approaches that combine parasite genetics, mobile phone data, travel surveys and models.
    1. Ecology
    2. Evolutionary Biology

    The African ape-like foot of Ardipithecus ramidus and its implications for the origin of bipedalism

    Thomas Cody Prang
    The most recent common ancestor of humans, chimpanzees, and bonobos possessed a foot adapted to terrestrial quadrupedalism and climbing.

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