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Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.

Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.

E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.

scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.

After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.

The cellular membrane competes with Abl for myristoyl binding to stabilize the preactivated state and enhance allosteric activation.

Based on benchmarking various methods and analyzing multiple real scRNA-seq datasets, a computational platform/workflow and a set of tips for best practices are developed for analyzing causal interactions or relationships in single cells.

Benzene mapping simulations of envelope protein rafts from six different flaviviruses reveal a conserved cryptic site whose cluster of ionisable residues is likely responsible for orchestrating pH-dependent conformational changes during fusion, thereby representing an attractive target for antiviral development.