Pain expectation processing shifts from uniform anticipatory activation to valence-specific differentiation during sensory input.

Microtubule-dependent movement of the glucose transporter GLUT4 is important for insulin-stimulated muscle glucose uptake, involves the motor protein KIF5B, and is impaired in muscle from diet-induced obese mice.

A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one's genetics and physiology increases its placebo effect on pain.

Statistical learning shapes pain perception by allowing the brain to predict and modulate pain intensity based on temporal patterns, providing insights into pain regulation and their relevance to chronic pain.

Novel small molecule inhibitors act against Neisseria including multi-drug resistant isolates by uniquely targeting RNR thereby enabling single pathogen therapy whilst sparing the microbiome.

Key variables required for pain perception in the context of a predictive coding model are correlated with distinct oscillatory profiles.

Combining computational models with FMRI in humans during pain reversal learning reveals parallel pain modulatory brain circuits that differ in their flexibility and sensitivity to instructions.

During CRISPR adaptation, Cas4 forms a ternary complex with the Cas1-Cas2 spacer integration complex, an interaction that coordinates substrate hand-off following precise, PAM-dependent prespacer processing prior to integration.

The integration of established psychological and biological models of pain suggests novel interventions to prevent pain persistence.

Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.