713 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

    Seyi Falekun et al.
    Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella et al.
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

    Thomas Hackl et al.
    Mutualistic viruses called virophages are common genome inhabitants of a marine protist, where they may protect host populations from giant viruses.
    1. Neuroscience

    A state space modeling approach to real-time phase estimation

    Anirudh Wodeyar et al.
    A statistically principled approach developed to estimate phase of rhythmic signals in real-time shows robustness to multiple sources of error and also provides confidence criteria.
    1. Immunology and Inflammation

    Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

    Xiaoting Wu et al.
    Inducible fate-mapping analysis demonstrates that neither microglia, CD11c+ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon et al.
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Neuroscience

    A projectome of the bumblebee central complex

    Marcel Ethan Sayre et al.
    Serial-section electron microscopy uncovers the intricate neural network of the bumblebee central complex, revealing highly conserved projection patterns as well as novel circuit elements potentially unique to bees.
    1. Epidemiology and Global Health

    Telomere length is associated with growth in children in rural Bangladesh

    Audrie Lin et al.
    In a rural, low-income setting in Bangladesh, early-life telomere length was associated with concurrent growth.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Information content differentiates enhancers from silencers in mouse photoreceptors

    Ryan Z Friedman et al.
    Silencers and enhancers targeted by a common transcription factor in photoreceptors are distinguished by the number and diversity of binding transcription factor binding sites they contain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Visualizing formation of the active site in the mitochondrial ribosome

    Viswanathan Chandrasekaran et al.
    GTPBP7, NSUN4, and MTERF4 facilitate maturation of the peptidyl transferase center of the mitochondrial ribosome.

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