A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.

Transposable elements and gene amplifications can provide variation needed for novel trait refinement and adaptation to new niches, though a recalcitrant organism-environment mismatch may persist.

The production, validation and study of a novel rat model for Phelan McDermid Syndrome shows an ameliorative effect of oxytocin on both social and attentional deficits.

To maximize broad insight on disease burden, seroprevalence studies should be generalizable to the wider population, both in age and location.

Mice exposed to complex early adversity show similar diffusion MRI changes to those reported in humans and sex-specific changes in connectivity that differentially affect contextual deficits in males and females.

The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.

Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.

CPT1A downregulation enhances radioresistance in colorectal cancer (CRC) via FOXM1-mediated antioxidant response, making it a potential biomarker for radiosensitivity and a novel target for improving CRC radiotherapy.

Electrophysiological and computational approaches show that superficial and deep cerebellar granule cells preferentially fire during low- and high-frequency inputs, respectively, enabling a Fourier-like transformation in the granule cell layer.