Cell-type-specific ribosome profiling during prion disease progression identified minor translational changes in neurons as well as profound glia changes many of which are shared with other neurodegenerative diseases.
Gata3 loss in prostate basal stem/progenitor cells upregulates BMP5 which is necessary and sufficient to sustain full self-renewal potential and its inhibition significantly delays both prostate and skin tumor progression.
Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
LOV2GIVe allows to activate Gi proteins non-invasively with innocuous blue light based on a design principle unrelated to light-activated GPCRs (metazoan opsins), thereby expanding the range of potential experimental applications.