321 results found
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer et al.
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic resonance mediates the state-dependent effect of periodic stimulation on cortical alpha oscillations

    Jérémie Lefebvre et al.
    Stochastic resonance, triggered by fluctuations in brain state, is found to determine the outcomes of periodic stimulation and how it interacts with brain oscillations.
  1. Research: Theory, models and biology

    Wenying Shou et al.
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
    Editorial
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    1. Evolutionary Biology
    2. Physics of Living Systems

    Adaptive Evolution: Can we read the future from a tree?

    Michael Lässig, Marta Łuksza
    Insight
    Available as:
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    1. Neuroscience

    Biophysics of object segmentation in a collision-detecting neuron

    Richard Burkett Dewell, Fabrizio Gabbiani
    Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Molecular structure of human KATP in complex with ATP and ADP

    Kenneth Pak Kin Lee et al.
    MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

    Robert M Cooper et al.
    Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.
    1. Epidemiology and Global Health

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Neuroscience

    Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

    Pengcheng Zhou et al.
    A new open-source computational toolbox for processing in vivo microendoscopic calcium imaging data performs signal demixing and denoising much more accurately than previously available methods, significantly improving the utility of this imaging modality.

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