741 results found
    1. Neuroscience

    Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits

    Balázs B Ujfalussy et al.
    Dendrites combine the inputs that they receive from other neurons using calculations that have been optimized for those particular input patterns.
    1. Neuroscience

    Task-dependent recurrent dynamics in visual cortex

    Satohiro Tajima et al.
    A decoding-based, state-space reconstruction reveals that neurons in macaque IT cortex change the structure of their collective attractor dynamics depending on task contexts.
    1. Computational and Systems Biology
    2. Neuroscience

    Biologically plausible learning in recurrent neural networks reproduces neural dynamics observed during cognitive tasks

    Thomas Miconi
    A biologically plausible learning rule allows recurrent neural networks to learn nontrivial tasks, using only sparse, delayed rewards, and the neural dynamics of trained networks exhibit complex dynamics observed in animal frontal cortices.
    1. Neuroscience

    Reverse-correlation analysis of navigation dynamics in Drosophila larva using optogenetics

    Luis Hernandez-Nunez et al.
    Optogenetic stimulation of odor- and taste-sensing neurons of the fruit fly larva combined with reverse-correlation analysis has been used to build mathematical models that predict navigational behavior.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui et al.
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A simple regulatory architecture allows learning the statistical structure of a changing environment

    Stefan Landmann et al.
    Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer et al.
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

    Sidney M Bell et al.
    Each dengue serotype contains moderate antigenic diversity, and population immunity drives clade turnover in a hyperendemic population.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

    Philipe RF Mendonça et al.
    A-type potassium conductances influence the distinctive firing behaviour of irregular-spiking interneurons.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

    Margaret A Myers et al.
    Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.

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