The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.
Temperature-dependent fasciation mutants of Arabidopsis unexpectedly connect mitochondrial RNA processing to the control of cell proliferation during lateral root morphogenesis via electron transport chain activity and reactive oxygen species production.
Submucosal glands are critical for two key respiratory host defenses, bactericidal activity and mucociliary transport, in an animal model that has lungs like humans.
While antimicrobial cocktails are highly effective for defence against pathogenic microbes, the innate immune response may instead employ highly specific peptidic antibiotics to combat certain natural enemies.
Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
STAG1 has been identified as a hardwired genetic dependency of cancer cells harbouring mutations in the cohesin subunit and emerging major tumor suppressor STAG2 holds the promise for the development of selective therapeutics.
Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.
