14 results found
    1. Chromosomes and Gene Expression

    Nonsense mRNA suppression via nonstop decay

    Joshua A Arribere, Andrew Z Fire
    Nonstop mRNA decay degrades mRNAs with a premature stop codon after such mRNAs are targeted by the nonsense-mediated decay machinery.
    1. Cell Biology
    2. Human Biology and Medicine

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha et al.
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
    1. Cell Biology

    Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

    Nicholas R Guydosh et al.
    A critical component of the cellular response to unfolded proteins is the widespread rescue of ribosomes that stall on endonucleolytically-cleaved mRNA transcripts.
    1. Cell Biology
    2. Neuroscience

    Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism

    Yongming Dong et al.
    The Sac1 phosphatase domain, rather than the proline-rich domain, plays an essential role in synaptojanin activity during endocytosis.
    1. Evolutionary Biology

    Long non-coding RNAs as a source of new peptides

    Jorge Ruiz-Orera et al.
    Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
    1. Physics of Living Systems
    2. Microbiology and Infectious Disease

    Cyanobacteria use micro-optics to sense light direction

    Nils Schuergers et al.
    The cells of a cyanobacterium act as spherical micro-lenses, allowing the cell to see a light source and move towards it.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

    Ryo Yonashiro et al.
    Rqc2-mediated modification of ribosome-stalled nascent chains with "CAT tails" promotes formation of insoluble aggregates suggesting that proteins can become specifically marked for aggregation.
    1. Cell Biology
    2. Neuroscience

    Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep

    Kun-Ming Ni et al.
    Cholinergic system play an important role in waking-to-sleep cycles and in sleep stabilization.
    1. Neuroscience

    Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

    Margarita Calvo et al.
    Type 1 potassium channels alter their composition and localisation to suppress hyper-excitability and neuropathic pain of injured sensory neurons.
    1. Developmental Biology and Stem Cells
    2. Chromosomes and Gene Expression

    Core promoter factor TAF9B regulates neuronal gene expression

    Francisco J Herrera et al.
    An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.

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