59 results found
    1. Neuroscience

    Human complex exploration strategies are enriched by noradrenaline-modulated heuristics

    Magda Dubois et al.
    Humans supplement complex, resource-demanding strategies with simple heuristics for solving the exploration-exploitation dilemma, and noradrenaline functioning controls their utilisation.
    1. Neuroscience

    Noradrenaline blockade specifically enhances metacognitive performance

    Tobias U Hauser et al.
    The neurotransmitter noradrenaline selectively modulates metacognition, the conscious insight into one's performance, but does not alter perceptual decision making, revealing that different neuromodulators affect different stages of a decision making process.
    1. Neuroscience

    Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin

    Lars Paeger et al.
    The coordinated differential modulation of satiety signaling POMC- and hunger signaling AgRP- neurons in the arcuate nucleus of the hypothalamus assigns an important role to noradrenalin to promote feeding.
    1. Neuroscience

    Catecholaminergic modulation of meta-learning

    Jennifer L Cook et al.
    A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons

    Stephanie C Gantz et al.
    In mouse brain slices, native delta glutamate receptors carry ionic current and underlie the α1-adrenergic receptor-mediated depolarization of dorsal raphe neurons that drives action potential firing in vivo.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller et al.
    Evidence for neuromodulatory control of flexibility in human neural models.
    1. Neuroscience

    Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation

    Josué Haubrich et al.
    The overactivation of noradrenergic inputs to the amygdala during severe fear learning increases memory stability at the expense of lability, rendering the trace resistant to memory destabilization and reconsolidation.
    1. Neuroscience

    Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

    Stefan Hirschberg et al.
    The locus coeruleus is organised into functional modules with subsets of noradrenergic neurones independently projecting to the spinal cord and prefrontal cortex to exert discrete, antithetical modulatory actions on a range of pain-related behaviours.
    1. Neuroscience

    The modulation of neural gain facilitates a transition between functional segregation and integration in the brain

    James M Shine et al.
    The flexible network architecture of the brain is sensitive to the modulation of neural gain, which may be mediated by ascending arousal nuclei, such as the noradrenergic locus coeruleus.
    1. Neuroscience

    Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action

    Jennifer C Swart et al.
    Motivational coupling of action to reward and inhibition to punishment is subserved by dissociable learning and choice processes, and is modulated by dopamine/noradrenaline transporter blockade.

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