60 results found
    1. Biochemistry and Chemical Biology

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Tingqing Guo et al.
    The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.
    1. Neuroscience

    A cortical disinhibitory circuit for enhancing adult plasticity

    Yu Fu et al.
    Building on previous work (Kaneko and Stryker, 2014), we report that the specific population of inhibitory neurons that increases the responses of neurons in the visual cortex during locomotion will also, when activated or blocked artificially, dramatically alter adult cortical plasticity, revealing that the aerobic exercise of locomotion is not necessary.
    1. Neuroscience

    Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin

    Mouloud Bouhadfane et al.
    The pain mediator bradykinin was found to sensitize spinal motoneurons by a direct postsynaptic action, questioning the role of motoneurons in the assessment of hyperalgesia since the withdrawal motor reflex is commonly used as a surrogate pain model.
    1. Neuroscience

    Sleep deprivation suppresses aggression in Drosophila

    Matthew S Kayser et al.
    A single night of sleep deprivation suppresses fighting behaviors in male fruit flies, with consequent impairments in reproductive fitness.
    1. Neuroscience

    Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

    William Menegas et al.
    Dopamine neurons projecting to different targets receive a similar set of inputs, rather than forming reciprocal connections, whereas those projecting to the posterior striatum receive a distinct set of inputs.
    1. Neuroscience

    Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish

    Chanpreet Singh et al.
    Experiments in genetically modified zebrafish that are unable to produce norepinephrine show that this neurotransmitter promotes wakefulness by mediating the effects of the neuropeptide hypocretin.
    1. Neuroscience

    An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

    Silke Frahm et al.
    Local elimination of acetylcholine synthesis in habenular neurons demonstrates a key role for vesicular synergy and neurotransmitter co-release in nicotine dependence.
    1. Neuroscience

    IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons

    Kang Wang et al.
    The slow afterhyperpolarization that follows a burst of action potentials is a powerful regulator of neuronal excitability and is not due to IK1 (KCNN4), a member of the SK channel family.
    1. Neuroscience

    Mouse V1 population correlates of visual detection rely on heterogeneity within neuronal response patterns

    Jorrit S Montijn et al.
    Heterogeneity of neural responses in mouse cortex correlates better with visual detection than mean population activity.
    1. Neuroscience

    Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

    Kwun Nok M Man et al.
    Munc13 proteins are key determinants of large dense-core vesicle (LDCV)-dependent catecholamine release in chromaffin cells.

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