23 results found
    1. Neuroscience

    Nostril-specific and structure-based olfactory learning of chiral discrimination in human adults

    Guo Feng, Wen Zhou
    Training-induced perceptual gain in the discrimination between odor enantiomers is nostril-specific and structure-based, indicating that early olfactory processing of the chemical features of unirhinal input remains plastic in human adults.
    1. Medicine

    Sensitivity of ID NOW and RT–PCR for detection of SARS-CoV-2 in an ambulatory population

    Yuan-Po Tu, Jameel Iqbal, Timothy O'Leary
    Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.
    1. Immunology and Inflammation

    Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

    Donal J Cox, Sarah A Connolly ... Joseph Keane
    The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory medicine.
    1. Developmental Biology
    2. Genetics and Genomics

    Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

    Mingi Hong, Annabel Christ ... Robert S Krauss
    A combination of window-of-sensitivity, genetic, and in vitro findings illuminate mechanisms of gene–environment interaction in a multifactorial model of a common birth defect.
    1. Neuroscience

    The role of oxytocin in delay of gratification and flexibility in non-social decision making

    Georgia Eleni Kapetaniou, Matthias A Reinhard ... Alexander Soutschek
    Oxytocin was found to significantly improve non-social decision making in a healthy sample, suggesting a domain-general function of the hormone, in contrast to its previously hypothesized social domain specificity.
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Neuroscience

    Sex-specific processing of social cues in the medial amygdala

    Joseph F Bergan, Yoram Ben-Shaul, Catherine Dulac
    Male and female mice respond differently to the same pheromone signals, and the representation of these sensory stimuli by neurons in the medial amygdala correlates precisely with the differences in behavior.
    1. Medicine
    2. Neuroscience

    Oxytocin administration enhances pleasantness and neural responses to gentle stroking but not moderate pressure social touch by increasing peripheral concentrations

    Yuanshu Chen, Haochen Zou ... Keith M Kendrick
    A randomized placebo-controlled trial with behavioral, neuroimaging, and physiological measures reveals that oxytocin treatment facilitates pleasure and brain reward responses only to gentle stroking social touch by increasing peripheral blood concentrations.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    High rates of evolution preceded shifts to sex-biased gene expression in Leucadendron, the most sexually dimorphic angiosperms

    Mathias Scharmann, Anthony G Rebelo, John R Pannell
    In the dioecious plant genus Leucadendron, shifts to sex-biased gene expression occurred predominantly in genes with ancestrally high rates of expression evolution, and were not correlated with morphology.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Panton–Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

    Bernadette C Young, Sarah G Earle ... Catrin E Moore
    Genome-wide association studies have established staphylococcal pyomyositis as a disease whose pathogenesis depends critically on expression of a single toxin, Panton–Valentine leukocidin.

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