The conserved mechanism of Notch down-regulation by endo-lysosomal trafficking plays important roles in the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis in vertebrates.
Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
Genetic analyses combining photoconvertible cell signalling reporters with gain- and loss-of function manipulations reveal a novel role for Notch signalling in controlling Hedgehog response in neural progenitor cells.
Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
Analysis of a variant without lysine in the intracellular domain reveals a ubiquitylation-independent signalling activity of the DSL ligand Delta and novel functions of the Neuralized and Mindbomb1 E3-ligases during Notch signalling.
Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.