4,844 results found
    1. Neuroscience

    Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking

    Jamshid Faraji et al.
    Social enrichment supports longevity.
    1. Genetics and Genomics
    2. Neuroscience

    Temporal transcriptomics suggest that twin-peaking genes reset the clock

    William G Pembroke et al.
    RNA sequencing reveals the finer details of circadian variation in the mammalian master pacemaker over 24 hours, which suggests that transcriptional timing influences clock resetting mechanisms.
    1. Structural Biology and Molecular Biophysics

    The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

    Akira Kawanabe et al.
    Electrophysiological and fluorometric studies of Ci-VSP expressed in Xenopus oocyte revealed two states of the enzyme region with distinct enzyme activity and distinct coupling to the voltage sensor.
    1. Immunology and Inflammation

    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

    Lieselotte SM Kreuk et al.
    Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
    1. Neuroscience

    Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans

    Bo-mi Song et al.
    The nematode worm C. elegans consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.
    1. Ecology
    2. Evolutionary Biology

    Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

    Anna-Liisa Laine et al.
    In natural pathogen populations opportunities for sexual outcrossing vary, leading to spatial variation in genetic diversity and between-season survival.
    1. Neuroscience

    Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments

    Jeremy D Cohen et al.
    Comparison of the intracellular activity of hippocampal neurons in novel and familiar environments reveals experience-dependent changes in inputs underlying the formation of stable representations of space.
    1. Neuroscience

    Normal cognitive and social development require posterior cerebellar activity

    Aleksandra Badura et al.
    Social and cognitive functions require normal activity during development of the posterior cerebellum.
    1. Neuroscience

    Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network

    Yaara Lefler et al.
    Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    High fat diet induces microbiota-dependent silencing of enteroendocrine cells

    Lihua Ye et al.
    Enteroendocrine cells sense nutrients in the gut and regulate digestive physiology but are rendered insensitive following fat ingestion due to alteration of gut microbiota.

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