956 results found
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

    Hui Che et al.
    A novel IVDD mechanism that involves p16 is demonstrated and theoretical evidence is provided for effective methods to downregulate p16 and so reverse IVDD.
    1. Cancer Biology
    2. Genetics and Genomics

    Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

    Jianing Xu et al.
    A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
    1. Cell Biology

    DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

    Brittany J Belin et al.
    An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

    Meredith A Sommars et al.
    B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.
    1. Ecology

    Endosymbiosis: Gasping for air

    Steven G Ball, Ugo Cenci
    Transcriptomics is shedding new light on the relationship between photosynthetic algae and salamander eggs.
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Hold your breath!

    Katharina Lust, Joachim Wittbrodt
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    1. Cell Biology

    Mitochondrial Homeostasis: Auto-regulation in the powerhouse

    Helena M Viola, Livia C Hool
    Mitochondrial flashes have a central role in ensuring that ATP levels remain constant in heart cells.
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    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Immune Response: An ambulance for retinol

    Stephanie C Ganal, Andrew J MacPherson
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    1. Ecology
    2. Evolutionary Biology

    Point of View: Managing a sustainable deep-sea ‘blue economy’ requires knowledge of what actually lives there

    Adrian G Glover et al.
    High-throughput, integrative taxonomy has a crucial role to play in ensuring that the resources in our oceans are managed and developed in a sustainable manner.
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?

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