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    1. Neuroscience

    Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock

    Andrea Brenna, Micaela Borsa ... Urs Albrecht
    The light-modulated protein kinase CDK5 is important for phase shifts of the circadian clock, impacting phase delays through calcium influx and signaling pathways, crucial for adapting to jet lag.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells

    Olivia Taylor, Nick DeGroff ... Andy J Fischer
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer

    Saima Usman, W Andrew Yeudall ... Ahmad Waseem
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

    Kira A Cozzolino, Lynn Sanford ... Dylan J Taatjes
    The Mediator-associated kinases CDK8 and CDK19 help drive inflammatory responses to interferon, and it is discovered that kinase-dependent transcriptional responses manifest in part through splicing changes and lipid metabolites.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

    Aleksandra Prochera, Anoohya N Muppirala ... Meenakshi Rao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

    Supratim Pradhan, Dhruba Dhar ... Budhaditya Mukherjee
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

    Erin M Ritchie, Dilan Acar ... Yishi Jin
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine

    Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Guillaume Martinez ... Jessica Escoffier
    Revised
    Reviewed Preprint v2
    Updated
    • Inadequate
    1. Microbiology and Infectious Disease

    The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

    Louise Tzung-Harn Hsieh, Belinda S Hall ... Rachel E Simmonds
    The secreted toxin mycolactone has severe effects on the cells lining blood vessels that will play a critical role in the development of swelling in Buruli ulcer disease.
    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected hosts and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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