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    1. Genetics and Genomics

    Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda

    Kevin H-C Wei et al.
    Heterochromatin is established at nucleation sites associated with open chromatin and RNA transcripts and matures into stable domains if they are found near transposable elements targeted by maternally deposited piRNAs.
    1. Cell Biology

    A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

    Uri Manor et al.
    An actin nucleating protein, Spire1C, localizes to the mitochondrial outer membrane and interacts with the endoplasmic reticulum-anchored formin protein INF2 to drive mitochondrial fission.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insight into TPX2-stimulated microtubule assembly

    Rui Zhang et al.
    A combination of cryo-electron microscopy of TPX2 bound to microtubules and in vitro reconstitution experiments reveals a novel microtubule interaction mode that explains how TPX2 promotes microtubule nucleation and stabilization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

    Benjamin A Smith et al.
    New insights into the mechanism responsible for the nucleation of branches on networks of actin filaments shed light on a process that is essential for eukaryotic cell motility and endocytosis.
    1. Cell Biology
    2. Physics of Living Systems

    Spatiotemporal organization of branched microtubule networks

    Akanksha Thawani et al.
    A sequential reaction pathway involving TPX2, augmin and γ-TuRC governs the assembly and architecture of branched microtubule networks.
    1. Physics of Living Systems
    2. Cell Biology

    Physical basis of large microtubule aster growth

    Keisuke Ishihara et al.
    Autocatalytic growth of a microtubule polymer network allows extremely large egg cells to self-organize and divide rapidly.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP

    Luke A Helgeson, Brad J Nolen
    Single-molecule TIRF microscopy, biochemical assays and mathematical modeling demonstrate how actin-branch nucleation by the Arp2/3 complex is coordinately regulated by two biochemically distinct activators.
    1. Cell Biology
    2. Physics of Living Systems

    Cortical microtubule nucleation can organise the cytoskeleton of Drosophila oocytes to define the anteroposterior axis

    Philipp Khuc Trong et al.
    A three-dimensional description of the cytoskeletal arrangement, cytoplasmic flows, and cargo transport in stage 9 Drosophila oocytes accurately reproduces mRNA localizations in wild-type and mutant oocytes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks

    Connor J Balzer et al.
    An activator of branching nucleation by Arp2/3 complex directly synergizes with an activator of linear filament nucleation to initiate assembly of actin networks that drive endocytosis.
    1. Cell Biology
    2. Computational and Systems Biology

    Microtubule reorganization during female meiosis in C. elegans

    Ina Lantzsch et al.
    Structural rearrangements of meiotic spindles during the transition from metaphase to anaphase can be controlled by local changes of microtubule dynamics, such as nucleation and/or turnover, and that katanin promotes microtubule turnover by severing microtubules near the chromosomes.