Animal RanBP1 nuclear export and cargo dissociation mechanisms are surprisingly different from yeast, due to mutations of critical residues, leading to greater nuclear transport efficiency and higher energy cost.
A combination of in vivo and in vitro approaches using Xenopus eggs and embryos reveals how dimensions of mitotic chromosomes scale with decreasing cell size and increasing nuclear-cytoplasmic ratio during early embryogenesis.
Clara Sidor, Nerea Borreguero-Munoz ... Barry J Thompson
The MASK family of proteins regulate the action of the YAP/TAZ family of transcriptional coactivators, key regulators of stem cell proliferation and cancer.
Anne C Meinema, Anna Marzelliusardottir ... Yves Barral
Acetylation of nuclear basket components, following their interaction with accumulating extrachromosomal DNA circles, drives the reorganization of nuclear pore complexes and the loss of cellular viability associated with replicative ageing.
Efficient targeting of membrane proteins from the endoplasmic reticulum (ER) to the inner nuclear membrane depends on GTP hydrolysis by Atlastin GTPases and their function in maintaining an interconnected topology of the ER network.
Christopher Duncan-Lewis, Ella Hartenian ... Britt A Glaunsinger
Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.
Eszter K Vladar, Miranda B Stratton ... Jeffrey D Axelrod
Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
Djamal Brahim Belhaouari, Gabriel Augusto Pires De Souza ... Sarah Aherfi
Metabolic pathways found to date in giant virus raise the question if these viral enzymes provide some level of autonomy to viruses or if they are used to expand the host metabolism.
Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
The patterns of chromatin architecture that underlie the initial embryonic cell fate decisions are established during a period of intense cell cycle activity, and these patterns are stably maintained even in highly condensed mitotic chromatin.
