62 results found
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Epidemiology and Global Health

    Development of a confinable gene drive system in the human disease vector Aedes aegypti

    Ming Li et al.
    Highly efficient and confinable split gene drives are a new tool for the control of the dengue mosquito vector.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

    Masahiro Oka et al.
    A key molecule that connects leukemogenic proteins to aberrant HOX gene regulation turned out to be a nuclear export factor, CRM1.
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies et al.
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.
    1. Cell Biology

    Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

    Grant A King et al.
    A meiotic nuclear remodeling event mediates cellular rejuvenation through elimination of senescence factors.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

    Kimberly Box et al.
    Early in mammalian epidermal development, basal epidermal progenitor cells utilize packing and three-dimensional geometry, rather than cortical polarity cues, to inform division orientation and progenitor cell fate.
    1. Cell Biology

    Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

    Irina L Rempel et al.
    In replicative ageing yeast cells, an age-dependent impediment in proper assembly of nuclear pore complexes is associated with altered nuclear transport.
    1. Cell Biology

    An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

    David J Thaller et al.
    ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
    1. Structural Biology and Molecular Biophysics

    Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

    Abhilash Padavannil et al.
    In an unusual complex that is not dissociated by RanGTP alone, Importin-9 sequesters the H2A-H2B core from promiscuous interactions.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

    David Alejandro Bejarano et al.
    Interaction of HIV capsids with the cellular protein cleavage-and-polyadenylation factor 6 at the inner side of nuclear pores promotes nuclear entry of the viral replication complex in primary human macrophages.

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