172 results found
    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics

    Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors

    Ximena Corso-Díaz, Xulong Liang ... Anand Swaroop
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Predicting the sequence-dependent backbone dynamics of intrinsically disordered proteins

    Sanbo Qin, Huan-Xiang Zhou
    SeqDYN, a sequence-based method, accurately predicts the residue-specific transverse relaxation rates of intrinsically disordered proteins.
    1. Cell Biology
    2. Neuroscience

    Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion

    Lu Yang, Zijin Lin ... Li Liu
    The established triple co-culture blood-–brain barrier (BBB) model could be used for predicting drugs’ BBB permeability, and co-culture with neurons and astrocytes enhanced brain endothelial cells’ integrity by secreting GDNF, which upregulated claudin-5 and VE-cadherin expression.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    HIV integrase compacts viral DNA into biphasic condensates

    Pauline J Kolbeck, Marjolein de Jager ... Willem Vanderlinden
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

    Patrick KA Kearns, Charles Dixon ... Nick Gilbert
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

    Yaping Chen, Pengcheng Zhou ... Di Yu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

    Viviane Kremling, Sven Falke ... Janina Sprenger
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

    Kejia Zhang, Patrick Eldin ... Dragony Fu
    SARS-CoV-2 infection reduces the intracellular levels of a human tRNA modification enzyme and alters host tRNA modification profiles.
    1. Biochemistry and Chemical Biology

    Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C

    Alexander S Baier, Nathan Gioacchini ... Craig L Peterson
    Nucleosome recognition by the SWR1C chromatin remodeling enzyme requires both nucleosomal acidic patches.
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