195 results found
    1. Chromosomes and Gene Expression

    Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

    Carmina Lichauco, Eric J Foss ... Antonio Bedalov
    Precocious ribosomal DNA replication in sir2 mutants requires Fun30.
    1. Genetics and Genomics

    A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

    Fan Zhang, Annie Lee ... Hong Xu
    A genetic screen and combined bioinformatic analyses revealed multiple novel transcription factors and their hierarchical organization in coordinating mitochondrial biogenesis.
    1. Structural Biology and Molecular Biophysics
    2. Genetics and Genomics

    Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters

    Jennifer Madrigal, Heidi L Schubert ... Christopher P Hill
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    Chromatin endogenous cleavage provides a global view of yeast RNA polymerase II transcription kinetics

    Jake VanBelzen, Bennet Sakelaris ... Jason H Brickner
    An alternative method for mapping RNA polymerase II occupancy over the genome provides new insights into the kinetics and molecular mechanism of transcription.
    1. Developmental Biology
    2. Genetics and Genomics

    ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

    Debashish U Menon, Prabuddha Chakraborty ... Terry Magnuson
    ARID1A is implicated in BAF-A-governed meiotic sex chromosome gene regulation and sex-linked chromatin dynamics in DNA repair.
    1. Immunology and Inflammation

    Diversity and functional specialization of oyster immune cells uncovered by integrative single cell level investigations

    Sébastien de La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin

    Maneesh Kumar Singh, Victoria Ann Bonnell ... Celia RS Garcia
    Multi-omic analyses reveal that the chromatin-associated microrchidia protein, MORC (PF3D7_1468100), at the blood stage of the human malaria parasite, Plasmodium falciparum, interacts with a range of nuclear proteins.
    1. Chromosomes and Gene Expression

    Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression

    Zulong Chen, Xin Wang ... Jessica K Tyler
    Genetic, cellular, and molecular analyses reveal that the reduced abundance of total nascent transcripts that occurs after irradiation is largely due to the repression of histone and rRNA encoding genes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

    Joseph A Bisson, Miriam Gordillo ... Todd Evans
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

    James Lee, Leman Simpson ... Lu Bai
    The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
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