237 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

    R Stefan Isaac et al.
    The inhibitory influence of nucleosomes on CRISPR-Cas9 is mitigated by nucleosomal DNA breathing and chromatin remodeling.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

    Ramasubramanian Sundaramoorthy et al.
    Structural models of the chromatin remodeling enzyme Chd1 in solution and when bound to chromatin indicate that conformational changes to both the enzyme and the nucleosome occur upon nucleotide dependent engagement.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

    Ramasubramanian Sundaramoorthy et al.
    The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling

    Krzysztof Brzezinka et al.
    Environmentally-mediated gene induction is extended beyond the duration of an external cue by sustaining a nucleosome-depleted chromatin structure.
    1. Biochemistry and Chemical Biology

    Dynamic regulation of transcription factors by nucleosome remodeling

    Ming Li et al.
    Single molecule DNA unzipping reveals a novel model for the regulation of transcription factors and nucleosome positioning via nucleosome remodeling in yeast.
    1. Biochemistry and Chemical Biology

    Stepwise nucleosome translocation by RSC remodeling complexes

    Bryan T Harada et al.
    Single molecule FRET reveals that the SWI/SNF-family remodeling enzyme RSC translocates nucleosomes along the DNA in steps of ~1-2 base pairs in size.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Nucleosomes influence multiple steps during replication initiation

    Ishara F Azmi et al.
    Nucleosomal DNAs assembled or modified by different chromatin remodeling enzymes differentially impact the origin licensing and helicase activation steps of replication initiation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Chromatin: Assembly, remodelled

    Karim Bouazoune, Robert E Kingston
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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A twist defect mechanism for ATP-dependent translocation of nucleosomal DNA

    Jessica Winger et al.
    Based on its nucleotide-bound state, the Chd1 chromatin remodeler can locally alter DNA twist on the nucleosome, which either pulls in or expels ~1 bp of DNA at the internal SHL2 binding site.
    1. Chromosomes and Gene Expression

    Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

    Oliver Willhoft et al.
    Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the Ino80 subunit.

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