Transgenic zebrafish generated by targeted genomic integration distinguish neuronal subtypes in the nucleus incertus that differ in their connections and functional properties.
Christian Thome, Jan Maximilian Janssen ... Maren Engelhardt
With the new Ankyrin-G-GFP reporter line, researchers can visualize and study neuronal compartments critical for signal transduction without affecting neuronal activity and subcellular integrity of the cells under investigation.
Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
Ceri Alan Fielding, Pragati Sabberwal ... Richard J Stanton
SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.
MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
Axon guidance genes are conserved regulators of neurodegeneration in Drosophila melanogaster and human inducible motor neuron models of UBQLN2-associated amyotrophic lateral sclerosis.
Male-type aggressive and courtship behaviors of the fruit flies are differentially specified by two sex-determining genes, providing a substrate for the evolution to sculpt these two behaviors independently.