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    1. Neuroscience

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala

    Linnaea E Ostroff, Emanuela Santini ... Eric Klann
    A diverse assortment of mRNAs are present in projection axons in the adult forebrain and their translation is associated with new memory formation.
    1. Neuroscience

    Genetically defined nucleus incertus neurons differ in connectivity and function

    Emma D Spikol, Ji Cheng ... Marnie E Halpern
    Transgenic zebrafish generated by targeted genomic integration distinguish neuronal subtypes in the nucleus incertus that differ in their connections and functional properties.
    1. Neuroscience

    Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

    Christian Thome, Jan Maximilian Janssen ... Maren Engelhardt
    With the new Ankyrin-G-GFP reporter line, researchers can visualize and study neuronal compartments critical for signal transduction without affecting neuronal activity and subcellular integrity of the cells under investigation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

    Weichen Song, Yongyong Shi, Guan Ning Lin
    Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

    Ceri Alan Fielding, Pragati Sabberwal ... Richard J Stanton
    SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.
    1. Neuroscience

    Representation of visual landmarks in retrosplenial cortex

    Lukas F Fischer, Raul Mojica Soto-Albors ... Mark T Harnett
    Retrosplenial cortex encodes landmarks by integrating visual inputs with other task-related variables in a supralinear fashion.
    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain, Carl N Wivagg ... Ethan C Garner
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Neuroscience

    Monkey plays Pac-Man with compositional strategies and hierarchical decision-making

    Qianli Yang, Zhongqiao Lin ... Tianming Yang
    Macaque monkeys play Pac-Man with strategy-based hierarchical decision-making, a cognitive capacity hitherto unknown in them.
    1. Cell Biology
    2. Neuroscience

    Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

    Sang Hwa Kim, Kye D Nichols ... Randal S Tibbetts
    Axon guidance genes are conserved regulators of neurodegeneration in Drosophila melanogaster and human inducible motor neuron models of UBQLN2-associated amyotrophic lateral sclerosis.
    1. Genetics and Genomics
    2. Neuroscience

    Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila

    Margot Wohl, Kenichi Ishii, Kenta Asahina
    Male-type aggressive and courtship behaviors of the fruit flies are differentially specified by two sex-determining genes, providing a substrate for the evolution to sculpt these two behaviors independently.