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    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

    Ramon A van der Valk, Jocelyne Vreede ... Remus T Dame
    The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
    1. Plant Biology

    A tension-adhesion feedback loop in plant epidermis

    Stéphane Verger, Yuchen Long ... Olivier Hamant
    Tensile stress patterns in tissues are revealed by cell-cell adhesion defects; in turn, cell responses to supracellular tension require cell-cell adhesion.
    1. Plant Biology

    The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway

    Nils Stührwohldt, Stefan Scholl ... Andreas Schaller
    Step-wise processing of plant peptide hormone precursors by subtilisin-like proteinases in consecutive compartments of the secretory pathway is required for formation and secretion of the bioactive peptides.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

    Benjamin C McIlwain, Roja Gundepudi ... Randy B Stockbridge
    In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli

    Deani L Cooper, Susan T Lovett
    The role of the bacterial protein RadA in homologous recombination – a DNA repair pathway vital to all cells – is defined.
    1. Neuroscience

    Voluntary and involuntary contributions to perceptually guided saccadic choices resolved with millisecond precision

    Emilio Salinas, Benjamin R Steinberg ... Terrence R Stanford
    Looking away from a salient visual stimulus pits the reflexive urge to look toward it against the voluntary intention not to, and this conflict is resolved within tens of milliseconds.
    1. Neuroscience

    Across-species differences in pitch perception are consistent with differences in cochlear filtering

    Kerry MM Walker, Ray Gonzalez ... Andrew J King
    Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
    1. Neuroscience

    Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds

    Simon M Danner, Natalia A Shevtsova ... Ilya A Rybak
    Organization of commissural and long propriospinal neuronal pathways defines gait expression in quadrupeds.
    1. Microbiology and Infectious Disease

    A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

    Rongsui Gao, Wenhui Wei ... Youjun Feng
    Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD+ metabolism.
    1. Cell Biology

    A novel live-cell imaging assay reveals regulation of endosome maturation

    Maria Podinovskaia, Cristina Prescianotto-Baschong ... Anne Spang
    A novel, inexpensive, easy-to-use method to analyse traffic along the endosomal pathway in mammalian cells shows that there is coordination between Rab conversion and acidification, but almost none between Rab conversion and recycling.