NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.

Widespread asymptomatic SARS-CoV2 infection affected nearly 100 million Indians by September 2020 with a subsequent decline in new cases, which may be attributable to increased population immunity, albeit seeing reduced neutralization activity at 6 months this respite may be temporary.

Sulforaphane through NRF2-dependent and -independent cellular and molecular pathways alleviates leptin resistance to reverse the diet-induced obesity.

Loss of FAD stemming from cell autonomous defects in mitochondrial proline catabolism impairs sperm quality male reproductive advantage in C. elegans.

TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.

Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.

Human metabolism-focused screens reveal clinically promising interventional strategies and repurposing targets to treat COVID-19.