871 results found
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair, Lorenzo Pedrotti ... Markus Teige
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

    Steffen Preissler, Claudia Rato ... David Ron
    Regulation of the endoplasmic reticulum chaperone BiP by calcium.
    1. Cell Biology
    2. Neuroscience

    Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

    Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
    Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.
    1. Developmental Biology

    Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

    Bryan Marsh, Yan Zhou ... Robert Blelloch
    Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

    Ali H Alghamdi, Jane C Munday ... Harry P De Koning
    Study of TbAQP2 adaptations and substrate interactions shows how this aquaglyceroporin enables cellular entry of large antimicrobial agents in Trypanosoma brucei.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter, Charlotte E Pelekanou ... David A Bechtold
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

    Gemma LM Fisher, César L Pastrana ... Mark S Dillingham
    A combination of structural, biochemical, single-molecule and in vivo methods are used to show how ParB locally condenses the bacterial chromosome near the origin and earmarks this region for segregation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells

    Roxane Verdikt, Abigail A Armstrong ... Patrick Allard
    Exposure of embryonic stem cells to physiological concentrations of Δ9-THC remodels cellular metabolism across differentiation.
    1. Computational and Systems Biology

    Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria

    Michael A Ferrin, Arvind R Subramaniam
    Collision between ribosomes can cause dissociation of stalled ribosomes from messenger RNAs during the process of mRNA translation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

    Sergi Junyent, Joshua C Reeves ... Shukry J Habib
    Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.

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