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    1. Computational and Systems Biology
    2. Ecology

    Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments

    Sylvie Estrela, Alicia Sanchez-Gorostiaga ... Alvaro Sanchez
    There are regularities in how specific nutrients combine together to shape the taxonomic composition of self-assembled communities, with some types of nutrients dominating other types.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke, Manuel Kleiner ... Stephanie Markert
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
    1. Cell Biology
    2. Cancer Biology

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao, Lifeng Yang ... Deepak Nagrath
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Ecology
    2. Microbiology and Infectious Disease

    Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing

    Heidi A Arjes, Lisa Willis ... Kerwyn Casey Huang
    Novel high-throughput co-culture assays reveal how the spatial structure of colony biofilms provides opportunities for nutrient and matrix sharing and may drive the evolution of cooperative behaviors.
    1. Cell Biology

    Translation in amino-acid-poor environments is limited by tRNAGln charging

    Natalya N Pavlova, Bryan King ... Craig B Thompson
    Amino acid limitation triggers preferential uncharging of glutamine-specific tRNAs and depletes polyglutamine tract-containing proteins from mammalian cells, revealing a potential role for polyglutamine tracts as sensors of glutamine sufficiency.
    1. Cancer Biology

    Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

    Keene L Abbott, Ahmed Ali ... Matthew G Vander Heiden
    Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.
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    1. Physics of Living Systems

    A multiphase theory for spreading microbial swarms and films

    Siddarth Srinivasan, C Nadir Kaplan, L Mahadevan
    A multiphase hydrodynamic theory reveals that the dynamics of colony expansion in microbial swarms and biofilms are limited by the constraints of water and nutrient availability.
    1. Evolutionary Biology

    The layered costs and benefits of translational redundancy

    Parth K Raval, Wing Yui Ngan ... Deepa Agashe
    Manipulation of the E. coli translation machinery sheds new light on evolutionary constraints and optimization strategies for bacterial translation and growth.
    1. Ecology

    Genomic adaptations in information processing underpin trophic strategy in a whole-ecosystem nutrient enrichment experiment

    Jordan G Okie, Amisha T Poret-Peterson ... James J Elser
    Trait-based metagenomic analysis of an ecosystem fertilization experiment shows that genomic traits that affect the costs and rates of biochemical information-processing mediate community assembly.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa

    Anita Szőke, Orsolya Sárkány ... Krisztina Káldi
    Molecular timekeeping in Neurospora crassa is robust even under severe limitation of carbon sources and the efficient adaptation to changing nutrient availability is dependent on the positive component of the circadian clock.