834 results found
    1. Developmental Biology

    A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

    Huanhu Zhu et al.
    A lipid acts to promote the development of nematode worm larvae through activation of an enzyme complex called TORC1.
    1. Developmental Biology

    A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

    Bin Qi et al.
    The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.
    1. Neuroscience

    mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

    Luke K Burke et al.
    AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
    1. Cell Biology
    2. Neuroscience

    Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

    Marta Palomo-Guerrero et al.
    The pseudoenzyme CPT1C is able to sense changes in intracellular malonyl-CoA levels caused by nutrients or energy stress and regulate late endosomes/lysosomes anterograde transport, necessary for proper axon growth.
    1. Neuroscience

    Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

    Ana I Domingos et al.
    Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.
    1. Plant Biology

    Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis

    Pengfei Cao et al.
    Despite BCAAs being de novo-synthesized in chloroplasts, TOR activation by BCAAs is conserved in plants and triggers a re-organization of actin and actin-associated endomembranes.
    1. Neuroscience

    A bidirectional network for appetite control in larval zebrafish

    Caroline Lei Wee et al.
    Brain imaging and behavioral analysis reveal two opposing states of hunger, represented by anti-correlated lateral and caudal hypothalamic dynamics that are important for the homeostatic control of feeding in zebrafish.
    1. Ecology

    Multistability and regime shifts in microbial communities explained by competition for essential nutrients

    Veronika Dubinkina et al.
    Multistability and regime shifts are common and species diversity is high in microbial communities when nutrient supplies are balanced and competing species have different stoichiometries of essential nutrients.
    1. Cell Biology

    Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila

    Susumu Hirabayashi, Ross L Cagan
    The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sex-specific transcriptomic responses to changes in the nutritional environment

    M Florencia Camus et al.
    Male and female Drosophila share core metabolic responses to different nutritional environments, but show opposing patterns of nutrient-dependent reproductive regulation.

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