526 results found
    1. Neuroscience

    Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

    Cristina Blázquez et al.
    Δ9-Tetrahydrocannabinol impairs motor coordination in mice by inhibiting autophagy in the striatonigral pathway, thus defining a new conceptual view of how cannabis acts in the brain.
    1. Neuroscience

    Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development

    Gabriela Manzano Nieves et al.
    Early life adversity (ELA) accelerated PV+ interneuron development in BLA and delayed the ability of pre-adolescent mice to express, but not form, an auditory conditioned fear memory in childhood.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis

    Tatsuhisa Tsuboi et al.
    Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.
    1. Neuroscience

    The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

    Amy A Worth et al.
    The GDF15 receptor, GFRAL,is expressed on a unique population of brainstem CCK neurons and mediates pathophysiological anorexia.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey et al.
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
    1. Neuroscience

    Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

    Lisa R Beutler et al.
    Neurons that promote hunger become desensitized to dietary fat in obesity.
    1. Microbiology and Infectious Disease

    Apoptotic neurodegeneration in whitefly promotes the spread of TYLCV

    Shifan Wang et al.
    A plant virus, Tomato yellow leaf curl virus, manipulates the host preference of the vector insect whitefly to promote its transmission by inducing caspase-dependent apoptotic neurodegeneration in vector's brain.
    1. Human Biology and Medicine

    Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

    Tiziana Squillaro et al.
    An update on the role of lncRNAs in adipogenesis and adipose tissue function, aimed at promoting the identification of new drug targets for obesity and metabolic diseases.
    1. Neuroscience

    Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

    Se Joon Choi et al.
    HCN and SK channel currents in striatal cholinergic neurons are decreased with dopamine loss, but only HCN is restored by chronic L-DOPA and SK abnormality persists in dyskinesia.

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