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    1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel et al.
    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.
    1. Biochemistry and Chemical Biology

    Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

    Vanja Panic et al.
    Mitochondrial pyruvate transport is required for brown fat thermogenesis.
    1. Biochemistry and Chemical Biology

    Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

    Sara M Nowinski et al.
    Mitochondrial fatty acid synthesis is best known for producing lipoic acid, however, longer acyl chain products regulate mitochondrial electron transport chain assembly, oxidative TCA cycle metabolism, and skeletal myoblast differentiation.
    1. Microbiology and Infectious Disease

    CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

    Kui Xu et al.
    The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells

    Xin Zhao et al.
    The generation and characterization of true β-catenin null mutant mice conclusively demonstrate that β-catenin is dispensable for T lymphocytes and leukemia stem cells, providing clarifications on a long-standing controversy.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov et al.
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.
    1. Developmental Biology
    2. Genetics and Genomics

    Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans

    Todd A Starich et al.
    Malonyl-CoA, the rate-limiting substrate for fatty acid synthesis, is produced in the soma and delivered through gap junctions to the germline to promote reproduction and coordinate it with nutritional status.
    1. Stem Cells and Regenerative Medicine

    Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

    Lisa Zipper et al.
    A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati et al.
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Epidemiology and Global Health
    2. Medicine

    A systematic review of population-based studies on lipid profiles in Latin America and the Caribbean

    Rodrigo M Carrillo-Larco et al.
    In Latin America and the Caribbean the most common dyslipidaemia seems to be low HDL-cholesterol, and there has been little change in time for both mean levels and prevalence estimates.