Cyclic peptide natural products didemnin B and ternatin-4 bind the same hydrophobic pocket of eEF1A to inhibit mRNA translation but exhibit kinetic differences that influence rate-limiting conformational changes underpinning aminoacyl-tRNA selection.

Newly developed methods to genetically target cerebrospinal fluid-contacting neurons reveal unique caudorostrally extended projections and recurrent connections in the spinal motor circuitry to control locomotion in mice.

Formation of dorsal axonal tracts in the spinal cord depends on multiple guidance mechanisms that control growth direction of bifurcating axons in the dorsal root entry zone.

Deep imaging, machine-learning-based segmentation, and tissue annotation resulted in a developmental series of 3D digital ovules with cellular resolution allowing next-level analysis of the ontogenesis of this complex organ.

Zona pellucida requires ZP4 protein to efficiently protect the developing embryo during in vivo pre-implantation development.

Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.

A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.

Silencing L2 neurons that project to C6 after a T9 contusion, effectively removing spared axons, results in improved paw placement timing and order, and normalizes speed-dependent changes in swing and stance representing a significant neuroanatomical-functional paradox for spinal cord injury.

A structural analysis of the transcription regulator Mot1 in complex with promoter DNA and the proteins TBP and NC2 provides a first structural framework for how a Swi2/Snf2 type remodeler interacts with a histone fold protein:DNA complex.

Calpain is a promising therapeutic target to reduce spasticity after a spinal cord injury.