270 results found
    1. Computational and Systems Biology
    2. Ecology

    Tree crickets optimize the acoustics of baffles to exaggerate their mate-attraction signal

    Natasha Mhatre et al.
    Tree crickets can optimize the baffles they make to increase call loudness without any progressive optimization, and manufacture an optimal baffle in a single attempt, by using a simple yet highly accurate heuristic.
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Developmental Biology
    2. Neuroscience

    Microscopy: Imaging far and wide

    Raghav K Chhetri, Philipp J Keller
    Insight
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    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Neuroscience

    Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons

    Daniel J Galtieri et al.
    Pedunculopontine neurons can evoke burst spiking in substantia nigra dopaminergic neurons without engaging a subtype of glutamate receptor previously thought to be necessary for this spiking mode.
    1. Ecology

    Sequestration and activation of plant toxins protect the western corn rootworm from enemies at multiple trophic levels

    Christelle AM Robert et al.
    The western corn rootworm escapes biological control by entomopathogenic nematodes by partitioning and phenocopying the plant defense system for self-protection.
    1. Cancer Biology

    Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

    Kevin M Elias et al.
    Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
    1. Human Biology and Medicine

    SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

    Saumel Ahmadi et al.
    Loss of an amino acid transporter and tissue depletion of nitric oxide worsens the intestinal function of CF mice, a finding that potentially explains variation in disease severity amongst CF individuals.
    1. Neuroscience

    Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice

    Claudia Villani et al.
    Lovastatin ability to rescue motor deficits and survival in a mouse model of Rett syndrome is strongly influenced by the genetic background.

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