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Microbiology and Infectious Disease
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of
Dennis Klug et al.
Exchange of the I domain in the Plasmodium surface protein TRAP against evolutionary distant I domains rescues infectivity of sporozoites.
Normal cognitive and social development require posterior cerebellar activity
Aleksandra Badura et al.
Social and cognitive functions require normal activity during development of the posterior cerebellum.
Epidemiology and Global Health
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Daniel W Belsky et al.
Methylation pace of aging is a novel measure requiring only a blood sample that clinical-trial and observational studies can use to test if treatments modify how fast participants are aging.
Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript
Tamar R Makin, Jean-Jacques Orban de Xivry
What can authors and reviewers do to keep common statistical mistakes out of the literature?
Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways
S Michael Rothenberg et al.
SOX2 causes resistance to anti-EGFR therapies in EGFR-mutant lung cancer.
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome
Laura Bozal-Basterra et al.
LUZP1 is required for proper cilia and cytoskeleton formation.
Genetics and Genomics
Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence
Diane Marie Keeling et al.
A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
Biochemistry and Chemical Biology
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
Aaron S Mendez et al.
A rationally designed small molecule ATP-mimetic activates IRE1 and PERK signaling in cells by inducing conformational changes that template the assembly of higher-order enzymatically active structures.
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
Jina Yun et al.
By reducing mitochondrial fusion, MUL1 compensates for the mutations in PINK1 or parkin that underlie certain cases of Parkinson's disease.
Bottom-up and top-down influences at untrained conditions determine perceptual learning specificity and transfer
Ying-Zi Xiong et al.
Perceptual learning is specific because of the absence of bottom-up stimulation and top-down modulation at the untrained conditions.
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