Phylogenetic and computational methods reveal that at least two seasonal coronaviruses are evolving adaptively in the region of the viral spike protein exposed to the human humoral immune system.
Andrew R Crowley, Harini Natarajan ... Margaret E Ackerman
Non-neutralizing antibodies to the SARS-CoV-2 spike protein’s S2 domain that also recognize widely circulating endemic coronavirus strains are rapidly boosted by natural infection but not vaccination with stabilized spike-based vaccines.
β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
Marloes Grobben, Karlijn van der Straten ... Marit J van Gils
SARS-CoV-2 infection and vaccination elicit antibodies that cross-react with other human coronavirus spike proteins, indicating the spike S2 subdomain as a potential target strategy to develop a pan-coronavirus vaccine.
Hanno Teeling, Bernhard M Fuchs ... Rudolf I Amann
Dynamic successive blooms of clades of planktonic marine bacteria that can be observed during blooms of marine algae follow discernible patterns, part of which might be explained by substrate-induced forcing.
An empirically derived scoring system for identifying optimal communication modules of aptazymes accelerates the development of ligand-responsive RNA genetic switches functional in mammalian cells.