1,236 results found
    1. Evolutionary Biology

    Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

    Kathryn E Kistler, Trevor Bedford
    Phylogenetic and computational methods reveal that at least two seasonal coronaviruses are evolving adaptively in the region of the viral spike protein exposed to the human humoral immune system.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike

    Andrew R Crowley, Harini Natarajan ... Margaret E Ackerman
    Non-neutralizing antibodies to the SARS-CoV-2 spike protein’s S2 domain that also recognize widely circulating endemic coronavirus strains are rapidly boosted by natural infection but not vaccination with stabilized spike-based vaccines.
    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash, Wenhui Wei ... Alan V Smrcka
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cross-reactive antibodies after SARS-CoV-2 infection and vaccination

    Marloes Grobben, Karlijn van der Straten ... Marit J van Gils
    SARS-CoV-2 infection and vaccination elicit antibodies that cross-react with other human coronavirus spike proteins, indicating the spike S2 subdomain as a potential target strategy to develop a pan-coronavirus vaccine.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Heidi Hehnly, David Canton ... John D Scott
    A protein kinase complex that is important for cell division is lost in testicular seminoma, which is a common cancer in men.
    1. Ecology
    2. Microbiology and Infectious Disease

    Host-microbiome metabolism of a plant toxin in bees

    Erick VS Motta, Alejandra Gage ... Nancy Moran
    The bee gut microbiota contributes to the metabolism of the cyanogenic glycoside amygdalin.
    1. Ecology
    2. Microbiology and Infectious Disease

    Recurring patterns in bacterioplankton dynamics during coastal spring algae blooms

    Hanno Teeling, Bernhard M Fuchs ... Rudolf I Amann
    Dynamic successive blooms of clades of planktonic marine bacteria that can be observed during blooms of marine algae follow discernible patterns, part of which might be explained by substrate-induced forcing.
    1. Cell Biology
    2. Neuroscience

    The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus

    Natasha M Puri, Giovanna R Romano ... Roshanak Irannejad
    Dopamine D1 receptor signaling from the Golgi apparatus in murine striatal medium spiny neurons is regulated by monoamine transporter OCT2.
    1. Biochemistry and Chemical Biology

    Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells

    Guocai Zhong, Haimin Wang ... Michael Farzan
    An empirically derived scoring system for identifying optimal communication modules of aptazymes accelerates the development of ligand-responsive RNA genetic switches functional in mammalian cells.

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