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    1. Neuroscience

    The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit

    Shruti Shankar, Jia Yi Chua ... Joanne Y Yew
    The cellular and molecular substrates that underlie the programmed behavioral response to a gustatory sex pheromone have been identified.
    1. Neuroscience

    Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off

    Verónica María Corrales-Carvajal, Aldo A Faisal, Carlos Ribeiro
    A quantitative video tracking analysis reveals that to gain the nutrients they need, flies change their decisions to exploit foods with different nutrient contents and explore the environment according to their internal amino acid and reproductive states.
    1. Genetics and Genomics
    2. Neuroscience

    Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

    Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri ... Pankaj Kapahi
    Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential consumption of excess nutrients offering preliminary insights into overconsumption of modern-day processed food.
    1. Cell Biology

    Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain

    Nadia Formicola, Marjorie Heim ... Florence Besse
    Tyramine-dependent signaling triggers decondensation of neuronal RNP components and rapid translation activation of target mRNAs.
    1. Developmental Biology
    2. Genetics and Genomics

    Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim

    Elizabeth M Knapp, Wei Li ... Jianjun Sun
    Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.
    1. Neuroscience

    A sleep state in Drosophila larvae required for neural stem cell proliferation

    Milan Szuperak, Matthew A Churgin ... Matthew S Kayser
    A role for sleep in developmental neurogenesis is revealed using a new system for studying sleep during nascent periods.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Non-classical amine recognition evolved in a large clade of olfactory receptors

    Qian Li, Yaw Tachie-Baffour ... Stephen D Liberles
    Fish trace amine-associated receptors evolved a novel structural motif that enables the detection of chemically diverse amine odors in a non-canonical 'inverted' orientation.
    1. Neuroscience

    Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs

    Jinfei D Ni, Adishthi S Gurav ... Craig Montell
    Functional imaging and circuit mapping in the Drosophila brain identifies neuropils where sleep-promoting and arousal-promoting neuronal networks converge.
    1. Neuroscience

    Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

    Ambra Masuzzo, Gérard Manière ... Julien Royet
    The universal bacteria cell wall component peptidoglycan impacts the egg-laying behavior of infected Drosophila females by directly modulating the activity of few brain octopaminergic neurons.
    1. Neuroscience

    TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions

    Zhiguo Ma, Marc R Freeman
    Astrocyte microdomain calcium transients are mediated by TrpML, stimulated by ROS and tyramine, and mediate astrocyte–tracheal interactions in CNS gas exchange.