464 results found
    1. Neuroscience

    Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance

    Su Z Hong et al.
    Neuromodulation of the expression of Hebbian plasticity enables rapid cortical sensory-induced remodeling in post-critical period adults, and can rescue deficits induced by prolonged sensory deprivation.
    1. Neuroscience

    Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

    Eitan S Kaplan et al.
    Parvalbumin-containing inhibitory neurons are crucial for expression of plasticity in adult visual cortex that supports visual recognition memory, but not for expression of ocular dominance plasticity that results from monocular deprivation.
    1. Neuroscience

    Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9

    Sachiko Murase et al.
    Light reintroduction (LRx) after dark exposure reactivates structural and functional plasticity in the adult mouse visual cortex by increasing the activity of MMP-9 at thalamo-cortical synapses.
    1. Neuroscience

    Sensory experience modifies feature map relationships in visual cortex

    Shaun L Cloherty et al.
    A new form of brain plasticity extends the known limits for how much early sensory input can alter the brain.
    1. Neuroscience

    Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits

    Anna R Moore et al.
    In vivo and ex vivo analysis of the activity-regulated gene Rem2 in the mouse visual system sheds new light on the contribution of intrinsic excitability in circuit plasticity.
    1. Neuroscience

    Response to short-term deprivation of the human adult visual cortex measured with 7T BOLD

    Paola Binda et al.
    Two hour deprivation of vision in one eye transiently boosts the representation of the deprived eye (suppressing the non-deprived eye) in adult human V1 and along the ventral pathway.
    1. Ecology
    2. Evolutionary Biology

    Why is cyclic dominance so rare?

    Hye Jin Park et al.
    A mathematical model for a popular biological diversity mechanism, cyclic dominance, is more likely to emerge by assembly than by evolutionary diversification, which rationalizes why few empirically studies find it.
    1. Neuroscience

    A cortical disinhibitory circuit for enhancing adult plasticity

    Yu Fu et al.
    Building on previous work (Kaneko and Stryker, 2014), we report that the specific population of inhibitory neurons that increases the responses of neurons in the visual cortex during locomotion will also, when activated or blocked artificially, dramatically alter adult cortical plasticity, revealing that the aerobic exercise of locomotion is not necessary.
    1. Structural Biology and Molecular Biophysics

    Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

    Yao Li et al.
    A multidisciplinary platform featured by patient-derived RPEs is established to study the disease-causing mechanisms of BEST1 mutations, and demonstrates gene-supplemented rescue of the mutation-caused deficiency in Ca2+-dependent Cl- current in human RPE.
    1. Neuroscience

    Rapid stimulus-driven modulation of slow ocular position drifts

    Tatiana Malevich et al.
    Slow, continuous changes in eye position when gaze is fixed, previously believed to be random drifts, are shown to exhibit highly systematic and short-latency response characteristics to visual stimuli.

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