443 results found
    1. Neuroscience

    Robust olfactory responses in the absence of odorant binding proteins

    Shuke Xiao et al.
    Although odorant binding proteins are widely believed to be required for transport of odorants to receptors, six types of sensilla of Drosophila respond robustly in their absence to many odor stimuli.
    1. Neuroscience

    Organization and function of Drosophila odorant binding proteins

    Nikki K Larter et al.
    A genetic analysis reveals that some olfactory sensilla of Drosophila do not require an abundant odorant binding protein and that one such protein may act in gain control.
    1. Ecology

    A moth odorant receptor highly expressed in the ovipositor is involved in detecting host-plant volatiles

    Rui-Ting Li et al.
    A moth can detect plant volatiles using an odorant receptor expressing in its ovipositor, and this odorant receptor has a much higher expression level in the ovipositor than antennae.
    1. Developmental Biology
    2. Immunology and Inflammation

    Symbiont-induced odorant binding proteins mediate insect host hematopoiesis

    Joshua B Benoit et al.
    Insect symbiotic bacteria regulate expression of an odorant binding protein that mediates an evolutionarily conserved hematopoietic pathway crucial for host immune system development and function.
    1. Microbiology and Infectious Disease

    A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

    Annemarie Voorberg-van der Wel et al.
    This comprehensive transcriptomic resource of dormant and replicating malaria liver parasites highlights the dearth of pathways that operate in the hypnozoites and the need to investigate druggability (i.e. selectivity and safety) of core pathways in malaria parasites.
    1. Evolutionary Biology

    The origin of the odorant receptor gene family in insects

    Philipp Brand et al.
    The insect odorant receptor gene family evolved at the base of the class Insecta before the evolution of flight and perhaps as an adaptation to terrestriality, and was therefore an important evolutionary novelty for insects.
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

    Srinivas Gorur-Shandilya et al.
    Olfactory receptor neurons adapt to odorant mean and variance and use complementary kinetics to preserve the timing of odorant encounters, despite adaptation slowing down transduction.
    1. Neuroscience

    Humidity response depends on the small soluble protein Obp59a in Drosophila

    Jennifer S Sun et al.
    Hygroreception, a poorly understood process critical to insect survival, depends on a small protein in the antenna of the fruit fly that was previously thought to transport odorants.
    1. Neuroscience

    Expanding the olfactory code by in silico decoding of odor-receptor chemical space

    Sean Michael Boyle et al.
    A computational method that can screen thousands of chemicals and predict which odorants will interact with specific odorant receptors in flies may ultimately aid the development of more effective insect repellents.
    1. Neuroscience

    Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

    David Cabañero et al.
    Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB2 receptor agonist that are mediated through CB2 receptors of neurons and lymphocytes.

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