A combination of genetic, anatomical and physiological techniques has revealed that the lateral horn, a region of the brain involved in olfaction in flies, has many more types of neurons than expected.
Odor conditioning induces two changes in olfactory neurons: non-associative sensory adaptation to odor history, and associative, bidirectional changes in behavioral output that are oppositely regulated in aversive and appetitive learning.
Serotonergic cells innervating the Drosophila antennal lobe are inhibited by odors and modulate olfactory responses in conjunction with the entire serotonergic network.
A high-throughput behavioral paradigm and computational modeling are used to decompose olfactory navigation in walking Drosophila melanogaster into a set of quantitative relationships between sensory input and motor output.
Mild myelin disruption leads to early axonal pathology, a novel pathological response in neural stem cells, regionally increased oligodendrocytes and altered behavior.
In naturalistic conditions, larvae of the Drosophila group exhibit species-specific strategies to search for food resources through a primitive form of risk-taking behavior that is controlled by a tradeoff between exploitation and odor-driven exploration.
A spiking network model that examines the transformation of odor information from olfactory bulb to piriform cortex demonstrates how intrinsic cortical circuitry preserves representations of odor identity across odorant concentrations.
Olfactory receptor neurons adapt to odorant mean and variance and use complementary kinetics to preserve the timing of odorant encounters, despite adaptation slowing down transduction.
