During adult neurogenesis in the olfactory bulb, microglia regulate the elimination (pruning), formation, and maintenance of synapses on newborn neurons, contributing to the functional integrity of the olfactory bulb circuitry.
Vax1 suppresses dopaminergic neuron phenotype by inhibiting Pax6 expression in the subventricular zone of the lateral ventricle and is necessary to generate Calbindin interneurons for the postnatal olfactory bulb.
Distinct lateral inhibitory circuits affect spiking in olfactory bulb mitral and tufted cells differently, which ultimately allows each cell type to best discriminate between similar odors in separate concentration ranges.
Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.