465 results found
    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin et al.
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Neuroscience

    Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

    Cesar Nava Gonzales et al.
    A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

    Srinivas Gorur-Shandilya et al.
    Olfactory receptor neurons adapt to odorant mean and variance and use complementary kinetics to preserve the timing of odorant encounters, despite adaptation slowing down transduction.
    1. Computational and Systems Biology
    2. Neuroscience

    Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures

    Gautam Reddy et al.
    Computational and theoretical analyses offer novel and unexpected insight into how complex, naturally occurring odor mixtures are parsed and normalized at the very first stage of olfaction.
    1. Developmental Biology
    2. Neuroscience

    The role of the NMD factor UPF3B in olfactory sensory neurons

    Kun Tan et al.
    The nonsense-mediated RNA decay (NMD) branch-specific factor UPF3B influences olfactory sensory neuron cell populations, the olfactory receptor repertoire, and antimicrobial gene expression.
    1. Computational and Systems Biology
    2. Neuroscience

    Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding

    Nirag Kadakia, Thierry Emonet
    In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Neuroscience

    Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila

    Noa Bielopolski et al.
    Muscarinic acetylcholine receptor type A in adult Drosophila inhibits Kenyon cells, and is required for aversive olfactory learning and learning-associated synaptic depression between Kenyon cells and their output neurons.
    1. Cell Biology
    2. Neuroscience

    Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice

    Ruchira Sharma et al.
    G protein-coupled odorant receptors regulate their own gene transcription based on their cell surface trafficking, which is facilitated by receptor transporting protein (RTP) family members.
    1. Neuroscience

    Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

    Carlotta Martelli, André Fiala
    Slow presynaptic depression in olfactory receptor neurons rescales combinatorial odor representations in postsynaptic neurons and mediates the encoding of stimulus mean and variance.

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