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665 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CRISPR-based functional genomics in human dendritic cells

    Marco Jost et al.
    A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau et al.
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Medicine

    Asprosin-neutralizing antibodies as a treatment for metabolic syndrome

    Ila Mishra et al.
    Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
    1. Computational and Systems Biology
    2. Ecology

    TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

    Tristan Walter, Iain D Couzin
    Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

    Shiou-Ru Tzeng et al.
    The N-terminal domains enable Lon protease to discriminate and capture selected protein species for degradation by exposed hydrophobic patches and flexible linkages to the hexameric core complex.
    1. Neuroscience

    Learning excitatory-inhibitory neuronal assemblies in recurrent networks

    Owen Mackwood et al.
    The synaptic structure in mouse V1 is explained by a synergy of homeostatic plasticity in incoming and outgoing synapses of inhibitory interneurons, establishing a stimulus-specific balance of excitation and inhibition.
    1. Immunology and Inflammation
    2. Neuroscience

    Sensing the world and its dangers: An evolutionary perspective in neuroimmunology

    Aurora Kraus et al.
    The investigation of neuroimmunology in non-model organisms is critical to diversify the field and identify primordial principles that govern neuroimmune communication across taxa.
    1. Medicine
    2. Neuroscience

    PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

    Edoardo Bistaffa et al.
    The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
    1. Cell Biology

    Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain

    Nadia Formicola et al.
    Tyramine-dependent signaling triggers decondensation of neuronal RNP components and rapid translation activation of target mRNAs.

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