426 results found
    1. Developmental Biology
    2. Neuroscience

    Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

    Luis Sánchez-Guardado, Carlos Lois
    Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
    1. Developmental Biology
    2. Neuroscience

    Retrograde Ret signaling controls sensory pioneer axon outgrowth

    Adam Tuttle et al.
    Long-range Ret receptor signaling promotes axon outgrowth and regulates growth cone dynamics in pioneer neurons by inducing transcriptional changes in Myosin-X expression.
    1. Neuroscience

    Brain Evolution: Adaptations to extreme conditions

    Barbara S Beltz
    The brain architecture of shrimp living in deep-sea vents provides clues to how these organisms have adapted to extreme living.
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    1. Biochemistry and Chemical Biology

    Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

    Joshua E Mayfield et al.
    The phosphorylation of tyrosine in the heptad repeat of the C-terminal domain of the largest subunit of RNA polymerase II promotes Ser2 phosphorylation by P-TEFb for pausing release.
    1. Cancer Biology

    Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

    Matthew F Pech et al.
    CRISPR/Cas9 screens reveal a role for the ubiquitin ligase substrate adaptor DCAF15 in the immune surveillance of cancer cells by natural killer cells.
    1. Neuroscience

    In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

    Morgane Roche et al.
    Brain temperature and oxygenation vary according to the imaging conditions during two-photon microscopy.
    1. Microbiology and Infectious Disease

    Nanoscale organization of rotavirus replication machineries

    Yasel Garcés Suárez et al.
    Super-resolution microscopy reveals, at nanometric-scale, the highly organized protein structure of viroplasms, the viral factories used by rotavirus to replicate its genome and assemble new viral particles.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye et al.
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Developmental Biology
    2. Neuroscience

    Lmx1b is required at multiple stages to build expansive serotonergic axon architectures

    Lauren J Donovan et al.
    A continuously expressed LIM HD factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of a long-range profusely arborized neuromodulatory axonal projection pathway.
    1. Neuroscience

    Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner

    Towako Hiraki-Kajiyama et al.
    In the brain of medaka fish, neuropeptide B acts directly downstream of estrogen in a female-specific but reversible manner to mediate female receptivity to male courtship.

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