291 results found
    1. Neuroscience

    A kinase-dependent feedforward loop affects CREBB stability and long term memory formation

    Pei-Tseng Lee et al.
    Through an image and behavioral screen based on MiMIC technology, we identified a novel kinase, CG11221 renamed Meng-Po (MP), and showed that flies that lack MP in mushroom bodies can learn but cannot remember as MP is required for the protein stability of CREBB.
    1. Neuroscience

    Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

    Kathrin Steck et al.
    Two different classes of taste receptor neurons in the Drosophila melanogaster proboscis play distinct roles in yeast feeding and are both modulated by the fly's internal amino acid state in order to promote protein-specific appetite.
    1. Cell Biology
    2. Neuroscience

    KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring

    Noriko Homma et al.
    Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
    1. Genes and Chromosomes
    2. Human Biology and Medicine

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Developmental Biology and Stem Cells

    Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior

    Alexandre Alié et al.
    A comparative approach shows that developmental evolution of neuropeptidergic neuronal groups in the hypothalamus of blind cavefish drives adaptive behavioral evolution.
    1. Neuroscience

    Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila

    Ashiq Hussain et al.
    Drosophila genetics and behavior reveal that oxidative stress induced axonal degeneration in a single class of neurons drives the functional decline of an entire neural network and the behavior it controls.
    1. Neuroscience

    Tracing neuronal circuits in transgenic animals by transneuronal control of transcription (TRACT)

    Ting-hao Huang et al.
    A new method that will allow researchers to visualize and genetically manipulate synaptically connected neurons in a brain circuit.
    1. Neuroscience

    Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward

    Zhijian Zhang et al.
    The VTA-mOT DAergic pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference.
    1. Neuroscience

    Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

    Shenqin Yao et al.
    Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
    1. Developmental Biology and Stem Cells

    Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm

    Raphaël Aguillon et al.
    Several neuronal subtypes found in the early zebrafish olfactory placode are not derived from the neural crest, as previously thought, but from the preplacodal ectoderm.

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