10 results found
    1. Neuroscience

    Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

    Jingjing Sherry Wu et al.
    Based on the animal’s recent history of sound exposure, cholinergic auditory brainstem neurons dynamically regulate dopamine synthesis for inhibitory feedback to the inner ear.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola et al.
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
    1. Neuroscience

    Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

    Wenxuan He et al.
    Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.
    1. Developmental Biology
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu et al.
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Neuroscience

    Principal cells of the brainstem’s interaural sound level detector are temporal differentiators rather than integrators

    Tom P Franken et al.
    Principal neurons of the brainstem nucleus comparing sound level at the two ears do not have the slow response properties previously attributed to them, but are instead specialized for fast weighing of excitation and inhibition.
    1. Developmental Biology
    2. Neuroscience

    Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons

    Thomas M Coate et al.
    The development of the mammalian cochlea undergoes a period of embryonic refinement in which the outer hair cell region repels incoming type I spiral ganglion neurons, thus ensuring these neurons instead form connections with inner hair cells.
    1. Neuroscience

    Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus

    Tenzin Ngodup et al.
    A major new class of neuronal cell type has been discovered in the auditory system, having features that make it a critical component of auditory processing.
    1. Neuroscience

    The human auditory brainstem response to running speech reveals a subcortical mechanism for selective attention

    Antonio Elia Forte et al.
    Selective attention to one of two speakers consistently modulates the response of the human auditory brainstem to each speaker's pitch.
    1. Neuroscience

    NOVA2-mediated RNA regulation is required for axonal pathfinding during development

    Yuhki Saito et al.
    The RNA-binding protein NOVA2 coordinately regulates the alternative splicing of key components in axon guidance and outgrowth pathways, with severe functional consequences.

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