90 results found
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

    Vivian Salgueiro, Jorge Bertol ... Rafael Prados-Rosales
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Epidemiology and Global Health

    Predicting the causal relationship between polyunsaturated fatty acids and cerebral aneurysm risk from a Mendelian randomization study

    Weijie Yu, Liwei Zhou ... Zhanxiang Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology

    A fat-2(wa17) suppressor screen in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Plant Biology

    Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

    Maryam Rahmati Ishka, Hayley Sussman ... Magdalena M Julkowska
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

    Linkang Wang, Haiyan Wang ... Ping Qian
    Bacillus velezensis has broad-spectrum antibacterial activity and can reduce the colonization of Salmonella Typhimurium in the intestinal tract of mice.
    1. Microbiology and Infectious Disease

    Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

    Yang Fu, Xiao-Dan Luo ... Wence Wang
    Lactobacillus plantarum regulates host uric acid metabolism via its own nucleoside hydrolase iunH.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
    Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.
    1. Developmental Biology
    2. Neuroscience

    The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

    Sebastián Giunti, María Gabriela Blanco ... Diego Rayes
    PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.
    1. Immunology and Inflammation

    LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization

    Hyun-Chae Lee, Sun-Hee Park ... Kyoung Seob Song
    PEGylated PDZ peptide reduces LPS-induced systemic inflammation, restores tissue integrity, decreases pro-inflammatory cytokines, and modulates macrophage populations, showing potential as a therapeutic for systemic inflammation.
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