90 results found
    1. Neuroscience

    Decoding a neural circuit controlling global animal state in C. elegans

    Patrick Laurent, Zoltan Soltesz ... Mario de Bono
    Sensory neurons that monitor ambient oxygen control a cascade of responses across multiple layers of interneurons to switch the global state of the nematode C. elegans, reprogramming behavior and gene expression to enable escape from or adaptation to surface exposure.
    1. Cancer Biology
    2. Cell Biology

    Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

    Edward Fielder, Tengfei Wan ... Satomi Miwa
    Late effects of radiation therapy in mice can be prevented by treatment with either senolytics navitoclax or quercetin plus dasatinib or the senostatic metformin.
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

    Lu Yu, Valerie P O'Brien ... Thomas J Hannan
    Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
    1. Structural Biology and Molecular Biophysics

    Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

    Ljuvica R Kolich, Ya-Ting Chang ... Damian C Ekiert
    Structure of MlaFB reveals how a small binding protein and the C-terminal tail on an ATPase subunit work together to regulate the assembly and function of an ABC transporter.
    1. Microbiology and Infectious Disease

    Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes

    William J Watterson, Melikhan Tanyeri ... Savaş Tay
    High-throughput droplet-based cultivation of gut microbes reduces biases of traditional cultivation strategies and thereby enables detection of difficult-to-culture organisms, which is required in applications such as antibiotic screening.
    1. Physics of Living Systems

    Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

    Albert Thommen, Steffen Werner ... Jochen C Rink
    A combination of experimental and theoretical analysis identifies body size-dependent energy storage as the physiological cause of 3/4-power law scaling of the metabolic rate in planarians.
    1. Microbiology and Infectious Disease

    Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

    Linkang Wang, Haiyan Wang ... Ping Qian
    Bacillus velezensis has broad-spectrum antibacterial activity and can reduce the colonization of Salmonella Typhimurium in the intestinal tract of mice.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

    Yun Pyo Kang, Laura Torrente ... Gina M DeNicola
    By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface

    Martin Houlard, Erin E Cutts ... Kim Nasmyth
    Chromosome condensation by condensin II is inhibited during interphase by direct interaction with MCPH1, which regulates opening of the condensin II interface between SMC2 and NCAPH2, in a similar fashion to how WAPL regulates Cohesin.

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