DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
Harriet Hunter, Dana de Gracia Hahn ... Jake P Mann
Animal studies of fatty liver disease over-estimate the benefit of drugs due to publication bias and are confounded by off-target weight loss, illustrating the challenge of successful translational across species.
Satvika Burugupalli, Adam Alexander T Smith ... Barwon Infant Study Investigator team
Plasma lipidomic profiling in pregnancy, infancy and early childhood provides a framework to define the relationship between lipid metabolism and health outcomes in early childhood.
Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker
A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.
Heli Julkunen, Anna Cichońska ... Nightingale Health UK Biobank Initiative
Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
The reclassification of gene editing as "GM" will impact on European plant sciences, making it more difficult to validate new traits in field trials and drive forward innovation.
