151 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
    1. Cancer Biology

    Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells

    Huanhuan Joyce Chen, Eric E Gardner ... Harold Varmus
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition

    Praver Gupta, Sayantani Kayal ... Tamal Das
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The fate of pyruvate dictates cell growth by modulating cellular redox potential

    Ashish G Toshniwal, Geanette Lam ... Jared Rutter
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Developmental Biology

    Flamingo participates in multiple models of cell competition

    Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D Axelrod
    In Drosophila, the planar cell polarity protein Flamingo is required by winners to maintain their status during cell competition in multiple models as they compete to occupy excessive territory within wildtype tissues.
    1. Cancer Biology

    Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

    Yang Peng, Jing Yang ... Liang Weng
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cancer Biology

    Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

    Trang H Pham, Kanika Bajaj Pahuja ... Anwesha Dey
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Cancer Biology

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling and phosphorylation of Akt and Erk in HPV16-infected cervical cancer

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

    Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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