Browse the search results

The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.

Lactic acid bacteria engage a hybrid metabolism which blends features of fermentation and respiration when they perform extracellular electron transfer.

Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.

daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.

Cell culture models widely used in cancer research do not reflect metabolism in tumors; by altering culture systems to better model tumor metabolism we find that environmental cystine promotes tumor glutamine metabolism.

Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.

The emerging importance of interorganellar communication is demonstrated by documentation of a feedback loop wherein peroxisome-generated metabolites affect mitochondrial ATP production and peroxisomal functions via signaling pathways requiring transmission of signals also through the cytosol and the nucleus.

Mitochondrial fatty acid synthesis is best known for producing lipoic acid, however, longer acyl chain products regulate mitochondrial electron transport chain assembly, oxidative TCA cycle metabolism, and skeletal myoblast differentiation.

Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.

Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.