378 results found
    1. Developmental Biology
    2. Neuroscience

    Learning steers the ontogeny of an efficient hunting sequence in zebrafish larvae

    Konstantinos Lagogiannis et al.
    Early hunting experience modifies the kinematics of hunting in larval zebrafish to increase the probability of successfully capturing live prey.
    1. Cell Biology
    2. Cancer Biology

    Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

    Bree K Grillo-Hill et al.
    Increasing the internal pH of cells can induce dysplasia and enhance oncogene-increased cell growth, while decreasing the internal pH combined with oncogene expression leads to synthetic lethality.
    1. Cancer Biology
    2. Cell Biology

    MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

    Timothy J Aikin et al.
    The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.
    1. Chromosomes and Gene Expression

    A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

    Virginie Olive et al.
    While intact mir-17-92 acts as a potent oncogene in a mouse model of Burkitt’s lymphoma, one of the six mir-17-92 components antagonizes its oncogenic cooperation with c-Myc by promoting c-Myc-induced apoptosis.
    1. Cancer Biology
    2. Computational and Systems Biology

    Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

    Rolando Ruiz-Vega et al.
    Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Cell Biology

    Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

    Jorge Vera et al.
    Greatwall is a new oncogene that induces AKT hyperphosphorylation by promoting the degradation of the phosphatase PHLPP.
    1. Cancer Biology
    2. Developmental Biology

    PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

    Genevieve C Kendall et al.
    The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

    Madeline Sandoval et al.
    Skin epithelium can tolerate oncogene-expressing clones through a novel cellular mechanism of inter-clonal competition between renewing progenitors along the clone's edge and differentiating progenitors within the clone's core.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel et al.
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.

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