1,147 results found
    1. Developmental Biology

    Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability

    Ethan J Greenblatt et al.
    Meiotic chromosome segregation in mature Drosophila oocytes is sensitive to prolonged quiescence, suggesting that human oocyte instability may result from storage of mature rather than primordial oocytes and be modifiable.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

    Linda Grigoraki et al.
    Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

    Daniel Coutandin et al.
    p63 uses an intricate network of domain-domain interactions to control its function in long-term quality maintenance of resting oocytes.
    1. Developmental Biology

    A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia

    Gonzalo Quiroga Artigas et al.
    Gamete release in the jellyfish Clytia is mediated by an opsin photopigment expressed in neurosecretory cells of the gonad ectoderm, which release an oocyte maturation hormone in response to light.
    1. Cell Biology

    A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

    Philippe Bun et al.
    On entry to meiosis, chromosomes scattered in the large oocyte nucleus of starfish are collected by an F-actin network, which contracts by an unexpected, myosin-independent mechanism based on local assembly and global disassembly of actin filaments.
    1. Cell Biology

    A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

    Madhuja Samaddar et al.
    A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.
    1. Immunology and Inflammation
    2. Medicine

    Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

    Daniela Fraccarollo et al.
    Immature CD10neg neutrophils and CD14+HLA-DRneg/low monocytes inducing proinflammatory and adaptive immune responses emerge in patients with large acute myocardial infarction.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Motility precedes egress of malaria parasites from oocysts

    Dennis Klug, Friedrich Frischknecht
    A surface protein triggers intra-oocyst motility of Plasmodium sporozoites to ensure parasite egress from oocysts.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming

    Miriam Samstein et al.
    Inflammatory monocytes carry live Mycobacteria from the lung to draining lymph nodes and acquire many characteristics of dendritic cells but fail to stimulate proliferation of CD4 T cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Immune surveillance of the lung by migrating tissue monocytes

    Mathieu P Rodero et al.
    Monocytes display distinct migratory and functional activity compared to dendritic cells and alveolar macrophages in the lungs.

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